PrintAlive BioPrints Living 3d Skin - Cell Layering On Substrate

Yes It’s Real PrintAlive BioPrints Living 3d Skin

Living 3d Skin Tissues Could Change Skin Grafting Forever?

We are seeing a profusion of breakthroughs in the bio printing space. This one shows so much promise. The PrintAlive BioPrints Living 3d Skin! That means that it has the potential to lead the way in replacing the normally very invasive and damaging skin grafting process.

I found the video a little hard to listen to, but if you advance to about 1 minute in you can see the magic happening! The video that shows the microfluidic cartridge-based technology outputting to what seems to me to be the roll of hydrogel. This is truly giving us a glimpse of the future now. This is a little factory. It fits into my proposition that we will soon be seeing Desktop Factories! Being a printer from way back this is a really familiar process!

PrintAlive BioPrints Living 3d Skin - Cell Layering On Substrate
PrintAlive BioPrints Living 3d Skin – Cell Layering On Substrate

Full Credit To Arianna McAllister and Lian Leng For Ground Breaking Work On PrintAlive BioPrints Living 3d Skin

Arianna McAllister and Lian Leng have developed PrintAlive BioPrints Living 3d Skin to create a bandage material that is compatible with human skin.  The methodology is very clever.  It reminds me of the traditional web printing process that I spent many years doing.  Depositing layers of cellular bases onto a substrate in a reel to reel process.

Interestingly the process I was working on is regarded as 2d Printing due to the viewers perspective.  The PrintAlive BioPrints Living 3d Skin is seen as a 3d process due to the interest in the unique properties that are built up in 3 dimensions.  These 3d properties allow the resultant composite mimic human skin.

PrintAlive BioPrints Living Skin In 3d - Cells Onto Hydrogel Substrate
PrintAlive BioPrints Living 3d Skin – Cells Onto Hydrogel Substrate
PrintAlive BioPrints Living 3d Skin - Cells Onto Hydrogel Substrate
PrintAlive BioPrints Living 3d Skin – Cells Onto Hydrogel Substrate

The The traditional processes has many limitations Compared To PrintAlive BioPrints Living 3d Skin

Skin can be taken from other parts of the body. This is technically referred to as a split-surface autograft. The obvious problem with this is that it can leave a scar if the skin taken is a decent depth or at the least it’s pretty darn uncomfortable. If the patient has suffered a major burn to a large area of skin, then this method is pretty much out of the question of course.

Acellular or cell-populated skin substitutes as well as cell-spraying strategies are problematic also. This is due to the time required to culture enough compatible cells to cover the required area of large surfaces. The process can take at least 14 days to complete.

Donour skin grafts also have the issue of possible transmission of pathogens and incompatibility. Allergic reactions can be triggered from traditional donour or artificial cells in quite a few cases.

PrintAlive BioPrints Living 3d Skin Appears To Be A Viable Solution To These Problems.

The Background To PrintAlive BioPrints Living 3d Skin

The project began in Axel Guenther’s lab at the University of Toronto as a MASc project for Lian Leng, and it continued as a MASc project for Arianna McAllister and a PhD project for Lian Leng.

“PrintAlive BioPrints Living 3d Skin” is the work of Arianna McAllister of the Biomedical and Mechanical Engineering University of Toronto Canada and Lian Leng MASc at the University of Toronto. Lian Leng studied at the Guenther Laboratory and from what I can gather is doing her Phd in microfluidic systems at the writing of this post.

It had been decided to use previously developed bioprinting technology for the deposition of a cell-populated bandage that would faithfully mimic the performance of compatible human skin. The method is also scaleable and produces the bandage tissues in high volume and in fast throughput.

Other Notable Work In 3d BioPrinting

Needless to say this project has gained significant attention. It is building on the body of breakthrough work in the Bio-Printing space.

Other significant work is being done by Oganovo. (ONVO)  and Biofab, amongst many others.

Conceptually the BioFAB 4500 3d Printer would use human stem cells to print complete structures, that ultimately would be targeting printing of 3d Human Organs for transplantation.  I can’t see anything definitive on where this technology is at, at this stage.

There is no doubt that if they can break through the red tape and technical hurdles this will be a huge benefit to people needing organ transplants.  Please see the video below that talks about how some of this technology works.

Picture (BioFab 4500)

BioFAB 4500 Aimed At Printing Complete Human Organs - Desktop Factory
BioFAB 4500 Aimed At Printing Complete Human Organs – Desktop Factory

A heart being theoretically being bioprinted on the BioFAB 4500 using human stem cells.  Yes, it is hotting up in the Bio-Printing space.

 

 

 

 

Yes It’s Real PrintAlive BioPrints Living 3d Skin






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